Ann Ehrenhofer-Murray is a professor of molecular cell biology at Humboldt-Universität zu Berlin. Ann studies the mechanisms of gene regulation by chromatin and RNA modifications. She initiated her studies on epigenetic gene silencing and histone acetylation as a postdoc at the University of California, Berkeley and expanded the work as an independent group leader at the Max-Planck-Institute for Molecular Genetics in Berlin. After professorships in genetics at the universities of Giessen and Duisburg-Essen, she returned to Berlin in 2013. Next to investigating the regulation of heterochromatin and centromeres through histone modifications, she more recently is studying the cross-talk of (t)RNA modifications and how they modulate protein translation.

Title of talk: Queuine links translational control in eukaryotes to a micronutrient from bacteria

M. A. Faghihi, M.D., Ph.D., is an Assistant Professor at The Department of Psychiatry & Behavioral Sciences at the University of Miami, Miller School of Medicine. Dr. Faghihi will also serve as a member of the Center for Therapeutic Innovation at the John P. Hussman Institute for Human Genomics. He received his medical doctorate (M.D.) degree from Shiraz University of Medical Sciences, Iran in 1994. He received his Ph.D. degree in Biomedical Sciences at the Karolinska Institute, Stockholm, Sweden in 2009. He served as a Senior Staff Scientist at the Department of Neuroscience at the Scripps Research Institute, Florida, before joining University of Miami. Dr. Faghihi is an expert in the field of RNA genetics, interested in non-coding RNA, particularly natural antisense transcripts and their involvement in neurological disorders such as Alzheimer's disease, Parkinson's disease, Multiple Sclerosis and Fragile X Syndrome.

Title of talk: BayanGene, Iranian Database of Annotated Human Variations.

Professor Stunnenberg is the Research Director of RIMLS/Faculty of Science, and coordinator of the EU FP7 High Impact Project BLUEPRINT (the BLUEPRINT of Haematopoietic Epigenomes) that runs from 2011-2016 ( and currently he is Chair of the International Scientific Steering Committee of the International Human Epigenome Consortium (IHEC).

Title of talk: The Epigenomic Blueprint of Stem Cells

Head of the genetic diagnostic lab, National Institute for Genetic Engineering and Biotechnology. PhD from Gothenburg University. Winner of ISSCO price 2014 as best biology researcher. In slamic counties. Winner of best Researcher in medical biotechnolgy in 2015 in Iran. More than 200 publications and 17 books.

Title of talk: Advanced genetic diagnostic

Philippe Froguel passed his Medical Degree in 1986 and he obtained a PhD in 1991 from Paris University. He is currently Professor of Genomic Medicine and head of the department genomics of common disease at the Hammersmith hospital, Imperial College London, UK. He is also Professor of Endocrinology at Lille University hospital, France, director of the CNRS/Lille University/Pasteur Institute research group "Integrated Genomics and Modelling of metabolic diseases", Director of the French laboratory of excellence on diabetes research EGID and of the equipment of excellence LIGAN-personalized medicine. PF's scientific carrier is focused on the genetics of diabetes and obesity. He is author of >630 Pubmed indexed publications and his H-index is 137. He is among the 400 most cited researchers in medical research (> 80,000). PF has identified in 1992 the first diabetes gene (glucokinase) and has published in 2007 the first Genome Wide Association Study in T2D.

Title of talk: The genetics aspects of obesity

Lucia Altucci is Associate Professor of General Pathology at University of Naples 2, where she is teaches the causal mechanisms of diseases with a focus on tumorigenesis to medical students, technicians and biotechnologists.Since 2014 she is collaborating with AVA and ANVUR taking part to the evaluating committee of Research centers, Universities and quality of researchers. She is Editor of the IJBCB (Elsevier) and of J Clinical Epigenetics (Biomed Central). She is part of many International committees for the evaluation of research in EU and outside.Lucia won the Presidential gold medal for her studies on Epigenetics & Cancer in 2010 and the price for cancer research given from the prestigious ‘Accademia dei Lincei’ in 2005.Her research focuses on innovative therapeutic strategies against cancer, (epi)drug discovery and development, identification of pathogenesis of diseases with a focus on cancer (epi)genome alterations.She is one of the founding members of the companies Mesogenics and Epi-C.v.

Title of talk: Cancer Epigenetics: From Basic towards Drug Discovery

Dr Ghader Mirzaghaderi was born in 1974 in Bokan, Iran. He obtained his BSc degree (1998) in the field of Agronomy and Plant Breeding from Urmia University, his M.Sc. degree (2001) in Genetics and Plant Breeding from Tarbiat Modares University, and his Ph.D. degree (2008) in Plant Breeding from Tarbiat Modares University. Dr Mirzaghaderi joined University of Kurdistan, Sanandaj, as academic staff in 2009 and am now serve as an associate professor in Agronomy and Plant Breeding Department, Faculty of Agriculture. His research interest areas are polyploidy, meiosis and wheat-alien interspecific hybridization.

Title of talk: Pivotal-Differential genome evolution in wheat

Priv.Doz. Dr. E. Korsching is PI of the Cancer & Complex Systems Research Group at the Institute of Bioinformatics of the University Hospital of Muenster. The studies in chemistry and biochemistry were brought to perfection in a PhD thesis on extra cellular matrix research. The present work focus has evolved from wet lab based research in cell and molecular biology (in a clinical setting) towards theoretical methods in biology. The foundations of the present work and the focus on clinical questions was established during the long standing research work in the pathology. The commitment to interdisciplinarity in research resulted in an ever growing research effort in theoretical biology, stimulated by the wealth of already existing mathematical and physical concepts. These concepts has been a source of inspiration in concrete research efforts in the field of breast and bone cancers. The present research program is centered around the biological reaction networks and how they form this robust and adaptive multi-cellular system. Beside these basic research efforts , which rely on simulation studies and analysis of array/sequence data sets, we apply those mechanistic insights to understand cancer formation and progression. Some further clinical projects focus on the definition of biological marker panels and quality standard.

Title of talk: Ewing sarcoma - How to create biological models from high dimensional data

Stephan Züchner, M.D., Ph.D., is a Professor and Chair for the Dr. John T. Macdonald Foundation Department of Human Genetics. He is a trained neurologist and molecular geneticist with research interests in identifying genetic variation associated with disease. His lab has identified several genes for Mendelian neurodegenerative disorders and also evaluated risk factors for complex genetic conditions, including Alzheimer disease, Parkinson disease, and obsessive-compulsive disorder. His lab is amongst the pioneering groups that have promoted genome sequencing methods for disease gene identification in humans, mice, and drosophilia. He is currently pursuing large-scale exome and genome analysis in multiple neurodegenerative disorders and develops innovative new software tools that allow real time shared analysis of large amounts of genomic data.

Title of talk: whole genome sequencing methods for disease gene identification in human

Dr. vahid khoddami,Vahid got his BS dergree in Medical Lab Sciences from Tehran University of Medical Sciences (Iran) and his MSc degree in Medical Biotechnology from Tarbiat Modares Univesity. In his MSc Vahid worked on implementation of RNAi in breast cancer cells. In 2007 he moved to United States for graduate school and got his PhD degree in Molecular Biology from University of Utah (USA) in 2013. After PhD he spent another year in Utah serving as Postdoctoral fellow at Huntsman Cancer Institute. In his PhD and postdoc in Utah, under the supervision Prof. Bradley cairns (HHMI investigator) he worked on developing novel technologies for transcriptomewide mapping of nucleotide modifications in RNA. In 2014 he moved to Boston to start his second postdoc at Harvard Medical School in the department of Cell Biology under the supervision Prof. Danesh Moazed (HHMI investigator) working on some interesting aspects of heterochromatin biology. In the fall of 2017 Vahid returned back to Iran and joined Royan Institute as an assistant professor. His main research interest is understanding the biological significance as well as clinical implications of RNA modifications and modified RNAs.

Title of talk: The Scope and Significance of RNA Epitranscriptome in Health and Disease

Dr. Martin Mascher,Head of the Domestication Genomics research group at the Leibnitz Institute of Plant Genetics and Crop Plant Research (IPK) in Gatersleben, Germany. Martin Mascher is a group leader at the Leibniz Institute of Plant Genetics and Crop Research (IPK) Gatersleben in Germany. His research is focussed on domestication and adaptation processes and their interaction with genetic diversity in cereal crops and their wild relatives. A mathematician by training, he received his Ph. D. in bioinformatics from the University of Bielefeld. Martin is interested in applying high-throughput methods in genomics and new computational algorithms to understand the genetic variation in germplasm collections of wild and domesticated plants.

Title of talk: Barley diversity now and 6000 years ago

Elahe Elahi is professor at the School of Biology at Tehran University. She received her Bachelor’s degree in Biology from the University of California at Berkeley in 1970, and her PhD from the University of Michigan in 1976. She did post-doctoral work at UCSF (University of California at San Francisco medical school), and returned to Iran just after the revolution at the end of 1979. Her research has been mostly on human medical genetics, but she occasionally diversifies into fields that include barcoding and bioinformatics. She and her colleagues identified FBXO7 as a causative gene of Parkinson’s disease, LTBP2 as a causative gene of primary congenital glaucoma, and CYP27A1 and ST6GALNA5 as causative genes of coronary artery disease by genetic linkage analysis and exome sequencing. Her emphasis has been on neurodegenerative diseases, and is presently trying to identify molecular pathways possibly involved in the etiology of glaucoma.

Title of talk: Another approach for identification of genes with roles in the pathogenesis of complex diseases

Prof. Peyvandi received her medical degree from the University of Milan, Italy, is certified in Haematology and was awarded PhDs from the Maastricht University, The Netherlands and the University of Milan, Italy for her research in the field of rare bleeding disorders. As part of her PhD thesis she was research fellow at the Royal Free Hospital, University College London, London, UK in 1997-98 for molecular characterisation of rare bleeding disorders and at the Veteran Administration Hospital, Harvard University, Boston, USA in 1998-99 for in vitro expression studies. Prof. Peyvandi’s basic and medical science research has focussed on the investigation of molecular mechanisms of coagulation disorders. Her research in the prevalence and mechanism of coagulation disorders aims at developing cost-effective treatment for the widespread treatment of patients. Dr. Peyvandi has authored and co-authored more than 360 scientific publications that have been published across well-known specialised journals (IF of about 1745, H index WoS of 49) and also 18 chapters in various books. Since 1999, she has been invited as an expert speaker at more than 128 national and international meetings and congresses. She has been the successful recipient of more than 40 project grants funded by Italian and International organisations and she was the principal investigator of the Establishment of a European Network of Rare Bleeding Disorders programme. She participates in clinical, educational and research activities in different parts of the world and she was Chair of the International Society of Thrombosis and Haemostasis (ISTH) Scientific and Standardization Committee on Factor VIII, Factor IX and Rare Coagulation Disorders. She is member of the ISTH council, member of the Executive Committee of the World Federation of Hemophilia (WFH), member of the executive committee of the European Association for Haemophilia and Allied Disorders (EAHAD) and member of the Medical Advisory Group of the European Hemophilia Consortium (EHC). In 2014 she was awarded the “Great Hippocrates” that is delivered to Italian medical researcher of the year.

Title of talk: Novel Therapies to treat hemophilia A

Dr. Masoud Garshasbi received his B.Sc. in Biology from the Ferdowsi University Mashhad, Iran (2001), and his M.Sc. in Human Genetics from the University of Social Welfare and Rehabilitation (USWR), Tehran, Iran (2003). He obtained his Ph.D. (2009) and Post doctoral (2011) in Human Molecular Genetics from Max Planck Institute for Molecular Genetics (MPIMG), Berlin, Germany by working on the genes involved in Intellectual Disability (ID). The outcome of his research was finding several novel genes for some of the inherited disorders. At 2011 he came back to Iran and since then he has been successfully active in both academia and private section. He joined as an assistant professor to the Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. He is founder and head of Medical Genetic Department at the DeNA laboratory, Tehran, Iran. He has also established the Medical Genetics department at the laboratory of Pars hospital, Tehran, Iran (2011-2013). Since 2011 he has been a part-time visiting collaborative member of the laboratory of Masih Daneshvari Hospital, Shahid Beheshti Medical Sciences University. He has published so far more than 40 research papers in peer review high ranking international journals (h-index:22). His main area of research is gene mapping and finding the mechanism behind the genetic disorders. He is a member of Iranian National Elites Foundation (INEF). In 2015 he has been chosen among the first 50 distinguished Iranian researchers by the Iran Saramadane Elmi Federation (ISEF). In 2014 he has been elected as a board member and also secretary of Iranian Society of Medical Genetics (ISMG) for three and half years..

Title of talk: Non Invasive Prenatal Testing (NIPT); experience of establishment and implementation into the clinical practice in Iran

Salvatore Oliviero, PhD Professor of Molecular Biology at University of Torino PI of the epigenetic unit at the Italian Institute for Genomic Medicine Between 1985 and 1988 at EMBL as PhD student he identified and characterized the inflammatory response elements in the acute phase gene. From 1988 to 1992, as post-doctoral fellow at Harvard Medical School mapped the FOS domains required for cellular transformation. From 1992 to 2010 as professor at the University of Siena identified new FOS-target genes involved in tumorigenesis. The most relevant was the identification and cloning of a new lymphangiogenic growth factor (VEGF-D). He described, for the first time, the molecular mechanism by which Myc regulates the elongation step of the transcription: he found that Myc-dependent phosphorylation of H3S10 triggers a cascade of epigenetic modifications that lead to the recruitmentnt of P-TEFb to the promoter. In 2010 moved to the University of Torino and IIGM. His lab is mainly focused on the analysis of epigenetic modifications that regulate gene fate. An important result of this researh was the demonstration that in stem cells bivalent developmental genes are kept hypomethylated by DNMT3L to ensure epigenetic plasticity through cell differentiation. His laboratory set up a number of transcriptome-wide techniques (CIRS-seq, SPET-seq) to profile cellular RNA structure and genome-wide methods (MAB-seq) to map and measure 5-formylcytosine and 5-carboxylcytosine at single-base resolution. Using this method he could unveil the DNA methylation dynamics that take place in promoters of highly expressed genes. He also found that DNA methylation on the gene body, which is mediated by DNMT3b recruited by H3K36me3, ensures transcription initiation fidelity by preventing RNA Polymerase II to initiate the transcription outside the canonical promoter, avoiding aberrant transcription initiations.

Title of talk: Regulation and Function of DNA methylation in stem cells

Dr. Danial Kahrizi, Agronomy and Plant Breeding Dept., Razi University, Kermanshah, Iran Danial Kahrizi is a professor of plant genetic engineering and molecular genetics at Razi University. He has been the head of Department of Plant Production and Genetics and head of Biotechnology Institute for Drought Research (BIDR) since 2003. In addition, He is the head and board chairman of Zagros Bioidea Co. He has authored or coauthored more than 120 journal articles, monographs, book chapters, and technical reports. He is Editor of Cellular and Molecular Biology in France. He has been editorial board membership of journals such as Gene, Plant Cell Reports and Molecular Biology Reports else. His interest is in plant genetic engineering, tissue culture and plant breeding (especially on oilseed plants such as Brassica napus and Camelina sativa) for drought tolerance. The first cultivar of Camelina has been released by Dr. Kahrizi in Iran. He produced more than 200 Camelina lines.

Title of talk: Camelina Genome and its similarities with Arabidopsis

Uwe KORNAK, M.D. Ph.D., is leader of a research group on hereditary connective tissue disorders at the Institute of Medical Genetics and Human Genetics, Charité-Universitaetsmedizin Berlin and the Max Planck Institute for Molecular Genetics, Berlin, Germany. During his Ph.D. training as a biochemist Uwe Kornak became involved in the generation and interdisciplinary analysis of in vitro and in vivo disease models for human disorders. Up to now he not only identified several genes associated with human disorders, but also analysed the effect of these gene defects using these disease models. Through his work as a human geneticist he has a broad experience with clinical and molecular genetic diagnostics of rare human disorders with a special focus on rare musculoskeletal phenotypes as well as common osteoporosis. As a basic researcher he is most interested in understanding the cellular pathophysiology of progeroid hereditary disorders of the skeleton and of connective tissues. An important focus has always been the regulation of trafficking and ion homeostasis of intracellular compartments. During the last years Golgi-related disease processes have become a large research focus. Uwe Kornak has been reviewer for different human genetics journals and is board member of the German Society for Human Genetics.

Title of talk:Genetics and mechanisms of progeroid connective tissue and skeletal disorders

Professor Fardin Fathi was born in Sanandaj, Iran. He studied anatomy at Tarbiat Modarres University and now is a full professor at Kurdistan University of Medical Sciences. He has started his research activity since 1380 and has published more than 50 papers in the field of stem cell biology and production of transgenic mice . He has established a center for stem cell research and producing transgenic mice in Kurdistan University of Medical Sciences. Dr fathi has produced various models of transgenic and knockout mice, including the first transgenic mous, the first cloned mouse and the first knockout mouse in Iran. He has passed three long-term training courses on stem cells and transgenic mice production in the Riken Institute of Japan and National center for producing transgenic mice in Czech Republic. Currently, his most research activity has been focused on the production of transgenic mice

Title of talk:Generating knockout mouse models using CRISPR-Cas9-Mediated Genome Editing

Mohammad Javan is a Professor in Cellular and Molecular Physiology at Tarbiat Modares University in Tehran. Mohammad got his PhD from Shahid Beheshti University in Tehran and had his postdoctoral training at Kyorin University School of Medicine in Tokyo. He joined Tarbiat Modares University in 2004 and stablished his lab for myelin repair and axon protection. He holds a second affiliation in Royan Institute for Stem Cell Biology and Technology at department of ​ Brain and Cognition ; as well as an associate membership at ICORD, University of British Columbia., He works on stem cell transplantation and on in vivo reprogramming of reactive astrocytes to myelinating cells and neurons. He is the council member of Iranian Society of Physiology and Pharmacology (ISPP) and the Editor in-chief of ISPP official English journal, Physiology and Pharmacology.

Title of talk: Genetic approaches to in vivo reprogramming of Reactive Astrocytes for neural Repair

دی ان ان